Momenta Pharmaceuticals, Inc. (MNTA)

[imnot6]

Fast and affordable IVIG analysis, brought to you by Momenta

I was poking around, ran across this from close to a year ago, and don't seem to recall (or find with a search) a previous mention of it. It seems to be a pretty advantageous technology (automated analysis using arrays of reagents compared to using a Mass Spec. to analyze IVIG).
Apologizes if I'm overreaching my tenuous grasp on the subject or repeating earlier posted info.

A Quantitative Microtiter Assay for Sialylated Glycoform Analyses Using Lectin Complexes, Journal of Biomolecular Screening, July 2015 -all MNTA authors

"We report here an elegant enzyme-linked immunosorbent assay (ELISA) approach...This assay thus potentially can provide revealing insights previously considered affordable only via the use of MS/chromatographic analyses....When applied to commercial-grade IVIG, this yielded quantitative data interpretable just as a data set generated by a LC/MS paradigm would have been, showing the same degree of clarity in subtle changes in the terminal glycan epitopes in rapid and high-throughput fashion.....
Recognizing that most therapeutic biologics are produced in recombinant expression systems, the application of the lectin assay was extended to screen expression systems for in-cell galactosylation and sialylation. ... In each case, testing the different recombinant Fc clones yielded a maximal glycosylation ranking, which matched closely with that obtained using MS analysis....Continued advances in glycomics leading to the discovery of lectins with novel specificities could potentially be incorporated into the assay described herein, allowing rapid screening of glycan epitopes in high throughput with no additional caveats associated with respect to sample preprocessing while keeping costs minimal."