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Re: biodoc post# 138047

Wednesday, 01/27/2016 1:41:03 PM

Wednesday, January 27, 2016 1:41:03 PM

Post# of 403159
Re:your first sentence:

if we have not seen safety for more frequent or longer duration dosing established, then how can phase 1 be over and how can phase 2's begin?

Sure it is safe when given once a week.

But Dana Farber/ctix/we do not know about side effects at other dosing.

How common is it for trials to move forward into phase 2 trials when the actual doses to be used have never been tested prev? Is it done all the time?

Still wonder if they are going to have to back down on the stated move straight to phase 2 for K for ovarian, pancreatic, renal, AML
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