Innovation Pharmaceuticals Inc (IPIX)

[slcimmuno]

P53 - Some oldies but goodies (more reading) I pulled on the dream that is drugging this pathway, given the newer rsch under discussion this past week... posts by KMBJN (our resident Teache), frrol, a-17, Infinity, xoc. Also came across some news on APR-246 (PRIMA-1) for prostate.

Long and holding fairly strong, still:

Banking on B
Betting on K
Bonus - P

Hopefully Monday's update will help further suss where we're at, where we're headed. 2016 shaping up to be rather telling.

Good w/e to all. El Niño starting to deliver snow to the Rockies, not as much to the Sierras, but no complaints.

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"Awakening Guardian Angels - Drugging the p53 Pathway" (Dec 2009)
http://dipbsf.uninsubria.it/monti/BFPN%202010/Biblio%20BFPN%202010/BFPN%20p53/drugging%20the%20p53%20pathway.pdf

"Targeting p53 by Small Molecules in hematological malignancies" (2013)
http://www.jhoonline.org/content/pdf/1756-8722-6-23.pdf

"The Tumor Suppressor p53: From Structures to Drug Discovery" (2010)
http://cshperspectives.cshlp.org/content/early/2010/02/08/cshperspect.a000919.full.pdf

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APR-246 / prima-1

"NUS researchers find new promise in old cancer drug" | TODAYonline (APR-246, colorectal)
http://m.todayonline.com/daily-focus/science/nus-researchers-find-new-promise-old-cancer-drug

https://www.csi.nus.edu.sg/ws/latest-csi/prima-1met-apr-246-inhibits-growth-of-colorectal-cancer-cells-with-different-p53-status-through-distinct-mechanisms-oncotarget-oct-2015-2

Dissertation
"Mechanistic Studies of APR-246 In Leukemia" (2013)
http://www.sfhem.se/upl/files/91697.pdf