Insmed Inc (INSM)

[Guaranteed Sceptic]

IGF1 Purification

I can't read the papers that you've listed recently, nor that cited by others, but TRCA could claim a difference between the fusion protein that your article's abstract mentioned and the intact, pure protein. This is particularly relevant given that injections of the pure protein (with or without binding protein) gives rise to some level of immune response. If the same protein were tagged with a c-myc or HA epitope or some other epitope for purification purposes, it could further stimulate an immune response. Also, the Nature paper that you cited a bit earlier would not likely include expression of the protein in E coli, judging by the abstract.

Best wishes from a long who is on vacation in Europe.

GS