Avid Bioservices Inc (CDMO)

[Protector]

Tradero, I think PPHM expected hockey stick opening of the clinical trial centers. Then Shan one mentioned to expect a bell-shape curve for the enrolment of the patients.

In a bell-shape, as such curve shows, it would be logical to expect the enrolment density to lower to the end. How this combines with a competitive enrolment I don't know, because in how I understand competitive-enrolment centers can keep enrolling until there region quota's are reached and so there is no STOP for any of the centers as long as the region isn't fully enrolled.

One would think, as you concluded, that competitive enrolment would indeed bring in more patients to the end because more centers are simultaneously enrolling. I always had a hard time to correlate that with a bell-shape UNLESS that shape would be the results of regions being fully enrolled and those centers not contributing any more.

In that case, as regions are more and more fully enrolled, the number of patients would go down more and more towards the end. That would make sense to me.

PS: I don't think that competitive enrolment goes that far as to allow, say, the European centers to over enrol their regional quota's as filed to compensate for, say, the USA.