Thursday, December 03, 2015 8:27:08 PM
Kevetrin is by no means alone. It is very common that a MTD is not reached. One example is Imbruvica (ibrutinib).
Pharmacyclics was bought by AbbVie for $21bn and Imbruvica (approved for CLL) has projected peak sales of $7bn.
The primary endpoint was to establish MTD. Due to low toxicity they never did so yet the drug is highly efficient.
Please tell me if you also consider the ph1 for Imbruvica a failure?
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