OncoSec Medical Inc (ONCSQ)

[guti]

IL-12 is a key mediator of communication between DC/Macrophages, Effector T-Cells and NK Cells

Expressing IL-12 will help confine the immune cells and bring the cells in with IL-12 in order to take the breaks off to get an effective immune response. The problem is that it is extremely toxin. However, EP IL-12 helps to get part one of the part two immune response.

“You get inflammation of the tumor, immune cell infiltrating, you get cytokine elaboration and that might be what you really need to synergize with the PD-1 antibody or another immune checkpoint inhibitor.“

And once combined with Teff checkpoints inhibitors like anti-PD1, part two of the immune response will take place by helping the non-responders.