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ZIOP Glioma 100% survival at approximately 150+ days or 5 months - Crosses BBB. REGULATED IL-12 turned on
First of all it should be noted that Intrexon synthetically made IL-12. It was injected into the brain in the off position and activated with the veledimex switch.
That has never been done before, and now it is proven in humans. Think platform technology.
" Ad-RTS-IL-12 and veledimex demonstrated tightly controlled expression of the potent immune cytokine interleukin-12. "
The side effects of IL-12 are well know - death.
Just Google Dr Rosenberg from NCI and read about the potential of IL-12
The companies ( XON/ZIOP) can't say this because its to early. However ...
The study shows - 100% survival at approximately 150+ days or 5 months ( 5 patients were dosed in June)
No deaths reported ( they must be reported within 24 hours )
" No significant adverse clinical signs observed "
From the poster - we can conclude that the platform is safe and effective
"Ad-RTS-hIL-12 + veledimex administered in patients undergoing tumor resection was well tolerated "
"Toxicity to date appears consistent with “on target” effect "
Veledimex crosses the blood brain barrier " shorts said can't be done
"Intra-cranial administration of Ad-RTS-hIL-12 is activated by oral veledimex " - proves the switch works in humans. In the human brain no less.
The platform is regulate
"Transcribed IL-12 peaked at Day 3 followed by downstream IFN ? "
See poster below on Ziopharm website
Notes from Dr Sam Broder at Stifel conference -
Intrexon is a platform technology
We have the solution - we harness a whole new paradigm
We are taking the immune system which has failed the patient and reprogramming it ...
We harness the immune system which will ultimately lead to a cures
We control expression
This will lead to enduring efficacy and scaleability
No systemic effects
Look at the quality of the institutions who have signed on to conduct trials- The best Dr's and hospitals in the world
Summary -
Wall Street probably sees this data as a yawn because they don't get the importance of controlling IL-12. See Dr. Rosenberg about importance.
However - this validates the rheo-switch.
The rheo-switch could be operating system for gene therapy in all human therapeutics.
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