Innovation Pharmaceuticals Inc (IPIX)

[To infinity and beyond!]

A bit of reading about ovarian ca. My knowledge of this is restricted to reading- I do not pretend to know the ins and outs of decisions about chemo, but I looked over the UP to Date (most commmonly used source of info for MDs)article about platinum resistant treatment options .

In short, there are a lot of options and nothing has any great efficacy. The recommendations are for paclitaxel, and doxorubicin, and others, incl gemcitabine. Also if BRCA + then olaparib. Other therapies mentioned are an angiogennesis -umab(long to write out), hormonal therapies(letrozole etc)

Docetaxel is mentioned, along with its significant toxicites, esp hematologic and nausea and vomiting(of course dose related).

Presumably CTIX tested K with all of these drugs and came up with docetaxel as most efficacious? Much is made of side effects in terms of choice of agent as next drug, for example, in the discussion of PLD(Doxorubicin)- given infrequently, few side effects etc. Would be nice for the company to say more about its choice, since the article does not list Docetaxel as one of the first few options .

The side effect discussion is of course a distant second to efficacy if efficacy can be shown with K.

The article is discussing a group of patients who are in a difficult spot- not responding to typical platinum regimens, with a relentless cancer, so side effects have real relevance.

Kevetrin has a real opportunity here, since current therapy has bleak prospects, and K thus far little in the way of side effects.