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Thursday, 11/19/2015 10:00:47 PM

Thursday, November 19, 2015 10:00:47 PM

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MRI images critically important so Fujifilm, we welcome you aboard with any offers you may have for investments as well : )

... Fujifilm Diosynth Biotechnologies

Mri contrast medium containing liposomes

EP 1888124 A1 (text from WO2006132403A1)

Inventors
Junji c/o FUJIFILM CORPORATIOND.
NISHIGAKI, Hiroyuki c/o FujiFilm Corporation
HIRAI, Masayoshi c/o FujiFilm Corporation KOJIMA,
Kazuhiro c/o FUJIFILM CORPORATION AIKAWA,

Applicant FUJIFILM Corporation

Abstract
A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.

https://www.google.com/patents/EP1888124A1?cl=en



Did this biotech truly come out of Fujifilm?

---------

Diosynth:

History

The company started in Oss, Netherlands[2] in 1923 with the extraction of insulin from bovine pancreas, and porcine insulin extraction in 1930, both of which are still part of their main products.[3][4][5] In January 2005, the company became a part of Organon, one of its sister companies in the Akzo Nobel pharma group.[6] Along with its sister companies Organon and Intervet were sold to Schering-Plough in March 2007 by Akzo Nobel.[7] Following the mergers of Schering-Plough with Merck & Co. (MSD) in March 9, 2009,[8] the company was part of the MSD Nutritionals products company, belonging to the MSD group.[9]

In April 2011, the company was sold to Fujifilm and Fujifilm Diosynth Biotechnologies was formed.

On December 18, 2014, Fujifilm Diosynth Biotechnologies acquired Kalon Biotherapeutic Technologies in College Station, TX, which became Fujifilm Diosynth Biotechnologies Texas, LLC.[11]

https://en.wikipedia.org/wiki/Diosynth



-------------------------

Digging deeper.... oh my.... some interesting names from the past



Cristina Brinkmann

Scientist 1 at Fujifilm Diosynth Biotechnologies
Raleigh-Durham, North Carolina Area
Biotechnology

Current

Fujifilm Diosynth Biotechnologies

Previous

Xencor, Peregrine Pharmaceuticals, The Scripps Research Institute

Education

UC Riverside

118
connections
...
...
...
...

Research Associate IV
Peregrine Pharmaceuticals
November 2004 – April 2009 (4 years 6 months)

Experienced with a variety of mammalian cell lines, both suspension and adherent

Successfully adapted cultures to serum free conditions

Subcloned monoclonal cell lines to ensure stability and improve specific productivity

Performed protein purifications from small to large scale (up to 150L of cell culture harvest)

Developed purification methods to take advantage of unique antibody characteristics

Performed various characterization assays, including LAL, SDS-PAGE, ELISA, Carbohydrate Analysis, Western Blot, SEC by HPLC

Executed blood cell isolation and cytokine analysis

Developed ELISA based analytical methods and optimized for individual cell lines

cGMP trained and proficient in technical writing; Routinely presented results to entire group

(Open)4 recommendations, including:

Claudia I Guevara
at Agensys/Astellas

I had the pleasure of working with Christina for 3 years. She brought to our group her expertise in protein purification and...View
Rich Archer

Senior Research Scientist at Peregrine Pharmaceuticals

While working with Christina on both associated and different projects I found Christina to be a hard working and...View

..
..
Projects
Antibody targeting of phosphatidylserine produces a cytokine microenvironment that enhances innate anti-tumor immune responses(Link)
April 2008

No. 4079: Monica L. Friedrich, Claudia I. Guevara, Daniel M. Falcon,
Longen Zhou, Connie Chang and Bruce Freimark, Antibody targeting of
phosphatidylserine produces a cytokine microenvironment that enhances
innate anti-tumor immune responses, Peregrine Pharmaceuticals, Inc.

Monica L. Friedrich, Claudia I. Guevara, Longen Zhou, Daniel Falcon,
Cristina Bautista, Michael Brown, Anita Kavlie,...more

(Open)7 team members, including:

Cristina Brinkmann
Scientist 1 at Fujifilm Diosynth Biotechnologies

Monica Friedrich
Faculty at Saddleback College

Claudia I Guevara
at Agensys/Astellas

Daniel Falcón

LONGEN ZHOU

Connie Chang

Bruce Freimark

https://www.linkedin.com/in/cristina-brinkmann-62a48a24








"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline."
-- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!

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