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Thursday, November 19, 2015 10:00:47 PM
... Fujifilm Diosynth Biotechnologies
Mri contrast medium containing liposomes
EP 1888124 A1 (text from WO2006132403A1)
Inventors
Junji c/o FUJIFILM CORPORATIOND.
NISHIGAKI, Hiroyuki c/o FujiFilm Corporation
HIRAI, Masayoshi c/o FujiFilm Corporation KOJIMA,
Kazuhiro c/o FUJIFILM CORPORATION AIKAWA,
Applicant FUJIFILM Corporation
Abstract
A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.
https://www.google.com/patents/EP1888124A1?cl=en
Did this biotech truly come out of Fujifilm?
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Diosynth:
History
The company started in Oss, Netherlands[2] in 1923 with the extraction of insulin from bovine pancreas, and porcine insulin extraction in 1930, both of which are still part of their main products.[3][4][5] In January 2005, the company became a part of Organon, one of its sister companies in the Akzo Nobel pharma group.[6] Along with its sister companies Organon and Intervet were sold to Schering-Plough in March 2007 by Akzo Nobel.[7] Following the mergers of Schering-Plough with Merck & Co. (MSD) in March 9, 2009,[8] the company was part of the MSD Nutritionals products company, belonging to the MSD group.[9]
In April 2011, the company was sold to Fujifilm and Fujifilm Diosynth Biotechnologies was formed.
On December 18, 2014, Fujifilm Diosynth Biotechnologies acquired Kalon Biotherapeutic Technologies in College Station, TX, which became Fujifilm Diosynth Biotechnologies Texas, LLC.[11]
https://en.wikipedia.org/wiki/Diosynth
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Digging deeper.... oh my.... some interesting names from the past
Cristina Brinkmann
Scientist 1 at Fujifilm Diosynth Biotechnologies
Raleigh-Durham, North Carolina Area
Biotechnology
Current
Fujifilm Diosynth Biotechnologies
Previous
Xencor, Peregrine Pharmaceuticals, The Scripps Research Institute
Education
UC Riverside
118
connections
...
...
...
...
Research Associate IV
Peregrine Pharmaceuticals
November 2004 – April 2009 (4 years 6 months)
Experienced with a variety of mammalian cell lines, both suspension and adherent
Successfully adapted cultures to serum free conditions
Subcloned monoclonal cell lines to ensure stability and improve specific productivity
Performed protein purifications from small to large scale (up to 150L of cell culture harvest)
Developed purification methods to take advantage of unique antibody characteristics
Performed various characterization assays, including LAL, SDS-PAGE, ELISA, Carbohydrate Analysis, Western Blot, SEC by HPLC
Executed blood cell isolation and cytokine analysis
Developed ELISA based analytical methods and optimized for individual cell lines
cGMP trained and proficient in technical writing; Routinely presented results to entire group
(Open)4 recommendations, including:
Claudia I Guevara
at Agensys/Astellas
I had the pleasure of working with Christina for 3 years. She brought to our group her expertise in protein purification and...View
Rich Archer
Senior Research Scientist at Peregrine Pharmaceuticals
While working with Christina on both associated and different projects I found Christina to be a hard working and...View
..
..
Projects
Antibody targeting of phosphatidylserine produces a cytokine microenvironment that enhances innate anti-tumor immune responses(Link)
April 2008
No. 4079: Monica L. Friedrich, Claudia I. Guevara, Daniel M. Falcon,
Longen Zhou, Connie Chang and Bruce Freimark, Antibody targeting of
phosphatidylserine produces a cytokine microenvironment that enhances
innate anti-tumor immune responses, Peregrine Pharmaceuticals, Inc.
Monica L. Friedrich, Claudia I. Guevara, Longen Zhou, Daniel Falcon,
Cristina Bautista, Michael Brown, Anita Kavlie,...more
(Open)7 team members, including:
Cristina Brinkmann
Scientist 1 at Fujifilm Diosynth Biotechnologies
Monica Friedrich
Faculty at Saddleback College
Claudia I Guevara
at Agensys/Astellas
Daniel Falcón
LONGEN ZHOU
Connie Chang
Bruce Freimark
https://www.linkedin.com/in/cristina-brinkmann-62a48a24
"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
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