Avid Bioservices Inc (CDMO)

[JamesGMS]

RRdog, Thank you for all your commentary and and for sharing your insights. A question below - in light of what appears to be your belief that Bavi may indeed be the “Real Deal” in the I/O space as exemplified by a few excerpted comments from your recent post:

There is an analogy hanging around this board that the PS/bavi platform is similar to the "Manhattan Project" that developed the atomic bomb. I think this analogy was first posited by MH. IMO there is real merit to this analogy, . . . . . .

In the immuno oncology world Dr. Wolchok is "The Man".

Were Dr.Wolchok ever to publicly acknowledge the PS pathway as primary in the immuno cascade and then link that pathway to Bavi and PPHM as the only patented mab in late stage human clinicals accessing that pathway, . . . . . . . .

The reasoning would be that "investors" could instantly see PPHM as a target for combos with existing drugs and as a target for multiple big pharma bidding.

IMO there are a number of scientists working on publications about this PS pathway. Again IMOO, it is only logical that sooner or later someone is going to link PS to Bavi and then to PPHM and--- eventually--- to the "massive patent advantage" PPHM has in this area.. Im sure you have all noticed how nobody ever makes this link----as of yet. . . . . . . .

Quietly, in a zero promoted scientific talk, Dr. Birge says his work indicates that PS is a Global Immuno Checkpoint.

This is exactly what was said by SK a couple of months back. To date it was the proverbial tree that "falls in the forest with nobody to hear it". Dr. Birge pretty much stuck to just PS without any further linkage. IMO this was as it should be under his MTA and NDA. Nevertheless, the implications of this statement are profound. I look forward to further work by Dr. Birge where he is less constrained.

. . . . . . . . The weight of the scientific argument is moving in PPHMs' favor.

Of course I would agree, if Dr. Wolchok were ever to come out publicly as you state above then INVESTORS would instantly pile into PPHM as you suggest - most likely moving the stock price seriously north immediately. But then “investors” are not really the concern here. Rather, it is BP that must be convinced - or at least one anyway - such that they can internally justify paying what would likely be deemed by the market to be a huge premium {I like to refer to as a "Pharmasett level" premium} to grab at least a piece of a Transformative Cornerstone Molecule - as well as it’s progeny of course.

So, to my question: With all the data now available, with all the publications underway to which you appear to be aware, and with the number of world class “collaborations” growing quickly, just how long - and only in your opinion of course - do you think it will take before there is enough data for any BP to develop an internal “GO” signal which would then allow them to become comfortable paying the hefty premium PPHM would rightly demand before giving anyone a piece of the Bavi et al pie?

Thanks again for your contributions.

James