Innovation Pharmaceuticals Inc (IPIX)

[rule_rationale]

I guess we'll have to wait for the trial design to be announced, however biodoc is correct that the 750mg/m2 dose in Phase I would be considered larger than the efficacy in the mice studies. The FDA guidance document from FDA.gov lists the conversion number for mg/kg to mg/m2 in mice at 3 ( 200mg/kg = 600mg/m2 for mice). They also list Human Equivalent Dose (HED) conversions, Mouse to HED for mg/kg is 0.08 so 200mg/kg mouse is 16mg/kg human. Converting 16mg/kg human back to mg/m2 is 592mg/m2 human, as compared to the 750mg/m2 dose in the Phase I.

Take this all as estimates, but numbers are from the FDA's 'Guidance for Industry' document.