In ZSPH 1-yr safety study: ~9% (61/683) pts reached 52-wk Thus the edema AE 7% will likely rise as the study progresses. Also ZS-9 has no effect on blood pressure
In RLYP 1-yr safety study: ~64% (194/304) pts reached 52-wk, it is cleaner and there is a marked lowering of blood pressure.
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