4 abstract hits under "Sleeping Beauty" (including some not under Ziopharm but "owned" by ZIOP/XON" ) at ASH Dec 4-8 Orlando - the largest and most important Hematology meeting in the world and of the yr.....
Pre-Emptive Donor Lymphocyte Infusion with CD19-Directed, CAR-Modified T Cells Infused after Allogeneic Hematopoietic Cell Transplantation for Patients with Advanced CD19+ Malignancies
Result Type: Paper
Number: 862
Presenter: Partow Kebriaei
Program: Oral and Poster Abstracts
Session: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Relapse
Time and Location:
Monday, December 7, 2015: 4:30 PM-6:00 PM
Tangerine 2 (WF2) (Orange County Convention Center)
Search Result:
... severe cytokine release syndrome since administered in a minimal disease state. Methods: We employed a non-viral gene transfer using the Sleeping Beauty (SB) transposon/transposase system to stably express a CD19-specific CAR (designated CD19RCD28 that activates via CD3z & CD28) in donor-derived ...
Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice
Result Type: Paper
Number: 412
Presenter: Gregory Vercellotti
Program: Oral and Poster Abstracts
Session: 113. Hemoglobinopathies, Excluding Thalassemia – Basic and Translational Science: Novel Mechanisms of Pathogenesis in Sickle Cell Disease
Time and Location:
Monday, December 7, 2015: 7:00 AM-8:30 AM
W340 (Orange County Convention Center)
Search Result:
... h, (mean ± SD, p<.05), demonstrating the protective role of HPX in SCD. To further test our hypothesis, we utilized Sleeping Beauty (SB) transposon-mediated gene therapy to overexpress rat HPX in NY1DD and Townes-SS SCD mice. Rat HPX plasmid (pT2/Caggs-HPX) was ...
Mitochondrial Biomass As a Measure of Fitness for T Cells Expressing Chimeric Antigen Receptors
Result Type: Paper
Number: 3242
Presenter: Bipulendu Jena
Program: Oral and Poster Abstracts
Session: 801. Gene Therapy and Transfer: Poster II
Time and Location:
Sunday, December 6, 2015: 6:00 PM-8:00 PM
Hall A (Orange County Convention Center)
Search Result:
... extra SRC (Windt et al., Immunity 2012). We therefore investigated whether subsets of CD19-specific CAR+ T cells after electro-transfer of Sleeping Beauty (SB) plasmids and propagation on activating and propagating cells (AaPC) could be identified based on SRC. Transmission electron microscopy ...
Use of Human Pluripotent Stem Cells to Model the Hematopoietic Defect and Repair of Human Telomerase Deficiency
Result Type: Paper
Number: 1212
Presenter: George Scaria
Program: Oral and Poster Abstracts
Session: 508. Bone Marrow Failure: Poster I
Time and Location:
Saturday, December 5, 2015: 5:30 PM-7:30 PM
Hall A (Orange County Convention Center)
Search Result:
... TERC mutant iPSC-derived cells. In order to rescue the hematopoietic defect in telomerase deficient TERC-mutant iPSCs we have used the Sleeping Beauty transposon system to over express these telomerase components TERC and TERT in the TERC mutant iPSCs. We are currently ...
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