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Monday, October 26, 2015 8:40:01 AM
Really? Did it really take this long to consider multi week dosing in a drug with a half life of a couple of hours? After months of no toxicity at ever higher doses?
It feels like the newer doing strategies are a year behind where they should be. I still wonder what toxicity might be evident with the new dosing. Is this when we see neutropenia?
Those with more pharmacology background feel free to criticize this line of thought, but the company seems slow to move forward with diffferent regimens. At this point they have established that the drug is safe when it is given as they do not wish to give it.
We have said phase 1 is all about safety.
After 3 years of testing safety is NOT established at the doses that are needed- consider that as we move forward
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