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Re: DewDiligence post# 196303

Friday, 10/23/2015 10:54:41 AM

Friday, October 23, 2015 10:54:41 AM

Post# of 251892

what those data mean for BLUE

That the old vector had a low transduction efficiency and as far as I can tell the current one has better titer and potency. Stability and durability are fine so far, for both vectors. If the patient had not been such a severe one, even the weaker vector could probably do better and longer.
Think the "GT nightmare scenario" is possible insertional oncogenesis more than low transgene expression.

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