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Wednesday, October 21, 2015 6:54:59 PM
Now, going back to my original post, which I can now take time to reference, https://blogs.shu.edu/cancer/2015/05/13/csf-1-inhibitor-plx3397-keytruda-anti-pd1-for-multiple-cancers/
One can see from the Medscape graph how low IL-12 relates to M2 macrophages by further reinforcing the M2 phenotype while suppressing CD8 + T cells, resulting in an overall immune-permissive environment for tumor growth and spread. Looking at the graph it shows why the need to regulate IL-12, since IL-12 is an interleukin that is naturally produced by macrophages. However, when a tumor is growing the Immune system does not recognize the need for IL-12 and in return drops their level due to the damaging loop that is taking place.
Dr. Pierce knows this and more, else, he would be talking out of his elbow when it comes to non-responders. And so would be Dr. Nghiem and Dr. Bhatia who only a few days ago at 2015 European Cancer Congress said “We believe this approach warrants further exploration in MCC, perhaps in combination with emerging systemic therapies, such as anti-PD-1/PD-L1 agents,” when referring to ImmunoPulse of IL-12 and Merkel Cell carcinoma.
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