Avid Bioservices Inc (CDMO)

[drragmop]

I did a little looking:

http://www.transmolecular.com/publications.htm

"Introduction: I-TM-601 is radiopharmaceutical that combines a 36-amino acid peptide, called chlorotoxin (designated TM-601), derived from scorpion venom with a medicinal isotope of iodine (I). TM-601 binds a receptor found on the surface of tumor cells, which is not found on normal cells. TM-601 binds many solid tumors types including glioma, breast, lung, prostate, and melanoma. No toxicities have been observed with the administration of TM-601 to rodents or primates. Its small size permits it to diffuse through tissues and across the blood brain barrier. A single dose of I-TM-601 administered intracranially to human xenografted mouse models of glioma has been shown to extend survival . . . ."

So they say it crosses BBB; but the tumor does appear to have been scooped: TM-601 is given by a "ventricular access device (VAD) placed in the tumor cavity at the time of resection. 14 to 28 days later, a single dose of a 2 ml solution of I-131-TM-601 is administered over a five min period via the VAD."

http://www.transmolecular.com/publications.htm