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http://www.bloomberg.com/news/articles/2015-10-09/astrazeneca-temporarily-halts-cancer-drug-combination-studies?cmpid=yhoo

AstraZeneca Plc said it temporarily halted two trials combining cancer drugs due to reports of lung disease.

The company stopped tests that combined its AZD9291 compound with durvalumab to treat patients with advanced non-small cell lung cancer after an increase in the incidence of interstitial lung disease-like reports, spokeswoman Esra Erkal-Paler said by e-mail, confirming a note to investors from Goldman Sachs Group Inc.

Patients enrolled in the trials, dubbed Tatton and Caural, will be given updated consent forms so they understand the new information and make a decision on whether to continue participating in the trials, she said. Tatton is an early-stage trial, while Caural is a late-stage test combining the two drugs.

AstraZeneca submitted lung cancer drug AZD9291 to U.S. regulators in June for approval. The company last year estimated peak annual sales of $3 billion for the drug.

The news may limit Astra’s ability to combine AZD9291 with other drugs and benefit U.S. rival Clovis Oncology Inc., which is developing a competing drug called rociletinib, Terence Flynn, an analyst at Goldman Sachs, said in the note.

Shares of AstraZeneca dropped 0.2 percent to 4,150.50 pence as of 9:35 a.m. in London trading.