OncoSec Medical Inc (ONCSQ)

[guti]

thanks Zoriden, I find it interesting that ever since Dr. Pierce got on board, Oncosec has tried to be one step ahead of the market when it comes to new approaches in Immunotherapy. The following is from a medical review on a study of the effect of electroporation on cardiac electrophysiology.

In the review, evidence was presented that electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and that electroporation can affect the outcome of defibrillation therapy, being both pro- and antiarrhythmic. Here, we present experimental evidence for electroporation in cardiac tissue, which occurs above a threshold of 25 V/cm as evident from propidium iodide uptake, transient diastolic depolarization, and reductions of action potential amplitude and its derivative. These electrophysiological changes can induce tachyarrhythmia, due to conduction block and possibly triggered activity; however, our findings provide the foundation for future design of effective methods to deliver genes and drugs to cardiac tissues, while avoiding possible side effects such as arrhythmia and mechanical stunning.