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Thursday, September 10, 2015 11:18:06 AM
Patent #8017368 is for a molecular delivery to cells using aspirin-related compounds.
The present invention provides for a system and method whereby aspirin and acetic acid help to permeabilize cell membranes to allow exogenous molecules to gain access to the cell interior. As such, the present invention provides a low cost drug and gene delivery tool that can be applied in combination with other molecular delivery methods. In an advantageous embodiment the method may further include the step of applying an electric field to the contacted membrane to electroporate the membrane.
From one of my recent post in YMB, "Scientists turn to aspirin to turbo-charge cancer immunotherapy."
Giving cheap aspirin to cancer patients may turbo-charge the effectiveness of expensive new medicines that help their immune systems fight tumors, experiments on mice suggest. In the experiments on mice, researchers used a mouse-specific anti-PD-1 which substantially slowed the growth of bowel and melanoma cancers in mice when compared with treatment by immunotherapy alone. They expect the aspirin effect to be similar with human medicines blocking PD-1, PD-L1 and another class of drugs targeting CTLA-4.
Immunotherapy promises to revolutionize cancer care by offering a better, longer-lasting response with fewer adverse side effects than conventional treatment, but the new drugs do not work well in all cases. With future immunotherapy use widely expected to involve multi-drug combinations, adding aspirin to the mix would be one way to help keep a lid on soaring costs.
These are two very good reasons why ImmunoPulse will be needed and why Aspirin wants to get in the mix. The difference will be in the aiming directly into the cells for reprogramming them and Dr. Heller is already a few steps ahead.
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