Avid Bioservices Inc (CDMO)

[asmarterwookie]

biopharm et al...AND goodjohnhunting..where are you? Yet another use for the APP?

Initially the pre-eclamptic placenta
is affected by oxidative stress (Hung et al., 2006). Reactive oxygen species (ROS) have been
recognized as secondary messengers in intracellular cascades, and endoplasmic reticular (ER)
stress has recently been identified as a major regulator of cell homeostasis (Zhang et al., 2008;
Cindrova-Davies et al., 2009). The ER serves many specialized functions in the cell including
synthesis, folding and transport of membrane and secretory proteins, and sequestration of
calcium ions (Ca2+). Protein folding and generation of ROS as a byproduct of protein oxidation
in the ER are closely linked events, and typical targets of ROS signaling are Ca²+ channels which
mediate both long-term as well as acute cellular responses to oxidative stress (Yung et al., 2008,
Redman et al., 2008).
Endothelial cell dysfunction has been identified as the final common pathway in the
pathogenesis of pre-eclampsia, but the stress response is wider: there are associated changes such
as the acute phase response and metabolic responses triggered by systemic inflammation
(Redman et al., 2009). The pathogenic role of soluble Endoglin (sEng) has been suggested in the
development of pre-eclampsia.

wook