Sunday, August 16, 2015 4:50:50 PM
I'd read over one of the key Peregrine Pharmaceuticals press releases, where they specifically mention that PS Targeting allows for the reduction by at least ==> because they cleverly said "more than : ) "<== 40% to MDSC's and that is a good thing. Actually, I've said it before in a post or two or more... that "NO OTHER" biotech has ever disclosed that the result of the MOA of any immunotherapy agent was capable of reducing MDSC's by as much as 40%. Now, we must ask more question.... would this large reduction in the area of MDSC's be part of much of the reason why PS Targeting combinations with PD-1/PD-L1..etc..etc allows for a statistically significant percent increase in ORR of 200-300% than without PS Targeting in the mix ? I say yes
I'd read this PR over again and look how Opdivo/Nivolumab/Keytruda..etc..etc makes mention that their drug "INTERACTS" with MDSC's and they never disclose how exactly they interact ?? lol Does Opdivo/Nivolumab/Keytruda..etc..etc and all others reduce MDSC's by 5% or up to at least 40% as Peregrine has revealed. My guess is those other IO drugs do not have anything close to the effect to restore and bring about optimal immune responses as PS Targeting (Bavituximab) does and that is why only Peregrine mentions the 40% reduction number in MDSC's. Next, are they going to be conservative with that percentage ? : ) I say yes...again. Always save the best for when you think you are given the best deal possible by some Big Pharma, then you bring out the best of the best facts that warrants the biggest biotech buyout of all time. Period.... and notice no question marks : ) No exclamation marks neither because one must remain calm at the bargaining table when one knows they have everything all other parties want and to the degree that illegal sabotage attempts/acts would be chosen by some as well.
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"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
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