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On the world's first lung cancer radioimmunotherapy drugs - beautiful green Vivatuxin
Poster: Wang Yu Bing 1197 people have visited
January 14, 2007, the world's first lung cancer radioimmunotherapy DRUG beautiful green (iodine [131I] tumor cell nucleus chimeric monoclonal antibody injection) Listing will be held in Beijing China World Hotel, Science and Technology, the Ministry of Health, the State Food Drug Administration related to leadership, the Asian Clinical Cancer Society (ACOS), Chinese Anti-Cancer Association of Clinical Cancer Studies Collaborative Professional Committee (CSCO) and the person in charge of the country more than 100 clinical cancer specialists participated will be listed. Lung cancer is the world's first killer, the world's new cases each year 1.2 million people, one person every 30 seconds die from lung cancer . In China, lung cancer incidence and mortality is also the highest cancer, cancer prevention is the most important task. For a long time, surgery, radiation therapy, although the control tumors have a good effect in terms of local lesions, but the prevention of tumor recurrence and metastasis has become powerless. Because lung cancer incidence of occult, once found often have lost the chance of operation and chemotherapy and therefore become an important tool, but chemotherapy harmful to human health, in lung cancer patients with advanced often due to inability to tolerate the pain of chemotherapy and give up treatment. With the rise of the monoclonal antibody technology, the radiolabeled monoclonal antibody has been used clinically, it has opened up new ways of treating cancer - radioimmunotherapy (radioimmunotherapy, RIT). Radiolabeled anti -tumor antibodies, injected into the body, the antibody with the corresponding tumor antigen, so as to lock the radioisotope in the tumor site, the radioactivity of the radioisotope continuous, eventually leading to tumor cell necrosis. Radioimmunotherapy is called "biological missile", which combines a monoclonal antibody targeting and killing effects of the strong internal radionuclides, with good efficacy, low side effects features. Currently, only two radioimmunotherapy drugs, the United States Biogen-IDEC's 90Y-ibritumomab (Zevalin) and Britain's GlaxoSmithKline 131I-tositumomab (Bexxar), and by the US FDA approved for lymphoma treatment. Zevalin and Bexxar is radionuclide labeled CD20 monoclonal antibody. Zevalin and Bexxar has been widely applied in Europe for lymphoma treatment provides a powerful weapon. We have reason to believe that in the near future, RIT will become cancer radiotherapy and chemotherapy, cancer molecular therapy and radiation therapy the perfect combination of new targeted therapies. Although RIT in lymphoma achieved such a significant effect of the treatment, but it is for the efficacy of solid tumors has been unsatisfactory. Mainly due to solid tumors sensitive to radiation is not that big. Meanwhile, in the conventional RIT is usually using membrane antigen monoclonal antibody. This led to a series of questions. First, the specific membrane antigen is not at all the tumor cell expression. In other words, the same lung cancer , there are many pathological types, different pathological type of tumor antigen markers vary. Even the same histological type, since the tumor cells expressing the heterogeneity of antigens will be different. And bound antibody also often because of degradation and the inner membrane antigen endocytosis, detached from the binding sites. For these reasons will cause the tumor site radiation dose relative lack of or antibodies to tumor lack of specific targeting, resulting in treatment failure. It is in this context, TNT ( tumor necrosis therapy) antibody emerged. Although TNT antibody development process is full of hardships and setbacks, but ultimately successful RIT overcome the problem in the treatment of solid tumors. Treatment of lung cancer new drug - aesthetic Health (131 tumor cell nuclei chimeric monoclonal antibody injection), is the Shanghai Biological Technology Co., mayne using US patented technology, after 12 years of successful research and development of radioimmunotherapy drugs. Many hospitals in the country nearly eight years of clinical studies indicate that aesthetic Health failed chemotherapy for advanced lung cancer patients have a significant effect, can also be checked after aesthetic injectable birth by radionuclide scanning, so that doctors can easily see if the drug accurate reach the tumor site, to further determine the therapeutic effect. 131I-chTNT (aesthetic Health) by the Chinese SFDA approved for chemotherapy failed for advanced lung cancer treatment. Beautiful listed for the majority of students failed first-line treatment of advanced lung cancer provides a new hope of life of patients. It is the main developer of aesthetic born American L.Epstein University of Southern California School of Medicine professor Alan presentation, TNT antibody locks only tissue degeneration and necrosis of solid tumors, 131I-chTNT and tumor cell nuclear antigen binding, in combination with monoclonal chTNT of radionuclides necrosis edge of tumor killing living cells, resulting in new necrosis, followed by expansion into new monoclonal chTNT necrosis, again and again so that tumor necrosis expanding from the inside out to destroy the tumor , for therapeutic purposes. Currently advanced lung cancer treatment are only 10% efficient, 5-year survival rate of less than 1%, most patients can not get effective treatment. It is reported that, 131I-chTNT treatment of lung cancer Phase II clinical trial in advanced lung cancer patients received 131I-chTNT injection, intravenous injection or injection route of tumor injection, the total effective rate was 34.6%. The trial proved that 131I-chTNT treatment of lung cancer is effective, but its side effects are also tolerated. Aesthetic born in China market, bringing a new treatment for the Chinese people lung choice, the majority of advanced lung cancer patients hope.
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Posted: 2011-10-08 14:49
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