I've been burned before for holding too long. I typically retain a core in these picks because it makes them easier to follow as I move on. To be successful in the market you have to set goals and move on when you achieve them. My goals were achieved, but I left a lot of money on the table with TPIV. Hindsight in the market is 20/20. I don't think anyone could have fathomed this would run from $.20 to over $1. I knew it was very undervalued, but I am astounded at how quickly the market is correcting itself. In the end, I made great money and the people who didn't sell are making life changing money. Everyone is a winner on AVXL, PTBI, TPIV, and TNXP.