Seneca Biopharma Inc fka SNCA

[Citrati]

Maybe this is the reason for move. Found it on internet post. I'll let the med/science posters weigh in.

Posted 03 June 2015 - 12:14 AM
I would like to explain what works for me. My anhedonia was SSRI induced, either by Zoloft or Fluoxetine.

My baseline Symptoms when unmedicated are - (10 being max, 1 being lowest impact)
No emotions - 10
No Pleasure from activities - 7
PSSD (No libido or sexual pleasure) - 8
Fatigue - 7
Disassociation. - 9

My journey to treating Anhedonia came from Forums, befriending people who are experts in pharmacology, and from other people's experiences.

The biggest impact started when i discovered a compound called NSI-189
http://en.wikipedia.org/wiki/NSI-189
http://www.longecity.../58442-nsi-189/

"NSI-189 is an experimental drug being studied by Neuralstem, Inc.[1] Research into NSI-189 has been funded by the Defense Advanced Research Projects Agency (DARPA) and the National Institutes of Health (NIH) for the treatment of major depressive disorder."
Poll results:
http://www.reddit.co...9_poll_results/

Now i was skeptical at the start, as it is currently going through FDA trials, and the risks long term are unknown. However, i weighed up the risk/benefits, considering i can no longer tolerate Anhedonia for much longer so i went for it.

Within 22 days of dosing, 2x 20mg sublingual of freebase NSI-189, i felt emotions again for the first time in years. Music gave me chills, watching fireworks gave me joy, everything felt real again.
The best part of NSI-189 is that it does not affect receptors directly, that we know of. The mechanism of action is still unknown, but we do know it is a potent neurogenesis agent and hippocampus growth agent.

The issue with SSRIs, is that it messes with the brain's equilibrium, it blunts our highs and our lows, and can even leave permanent impacts well after the drug is discontinued. I believe NSI-189 is going to be a hit when it finishes trials and comes on the market.

To try and reverse the damage to receptors / SERT from SSRI use, Saint John's Wort can be used to upregulate 5HT1A, 5HT2A, and the main goal here is to reverse the action of SSRIs. St John's wort can bring back sexual function and emotions via 5HT1A upregulation.

Even though NSI-189 lifted my mood, dropped my disassociation, and brought on emotions, my sexual function was still impaired by SSRI use. St johns wort, or anything with 5HT2C antagonism (Agomelatine) would be helpful for this.

My mood score on NSI-189:

No Emotions - 3
No Pleasure from activities - 3
PSSD - 7
Fatigue - 3
Disassociation - 5

Huge improvement from one compound. I am trialling combinations to bring myself closer to 100%.
Thanks for reading.