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Wednesday, June 03, 2015 9:50:46 PM
Look, I agree with you on those points , which are quite well-stated. Wish I had written it.
What else can one say: if there was some agreement with DFC, maybe things have changed?? Think about the hoopla with the spleen lesion-that was a big splash and was released, so is there a change? Hard to know why the dynamic would be different now. But they have not released the p21 data that CEO has said is positive
But there is something up, though. Look at all of those patients with ovarian and uterine cancer in the last 2 cohorts. It just cannot be a coincidence. In the halls of Dana Farber there must be a sense that something is happening for those patients and they are getting referred for Kevetrin, and it would have to be something positive. Look, I would just as soon not see this. I would rather have Kevetrin work for all types of patients, and maybe it will, and I would rather see all sorts of cancers in the later cohorts. But it stands to reason that Kevetrin will benefit some more than others(Here of course we only speak of monotherapy- we have NO DATA sadly on combo treatments, other than a statement from BIDMC that it works well with sunitinib)
Someone had a 205% increase in p21- prob later cohort
Very interesting to see what data to emerge re efficacy
Next ASCO-2016- for real data sets? Will we have to wait that long for the new protocols to get results? Probably.
I suppose then my overall sense is that there is something brewing that is good but that results are tightly under wraps. Even though there were no wraps before?!
Maybe that is what I want to believe. No inside info here.
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