Kraig Biocraft Laboratories Inc (KBLB)

[first mike]

Hi Jazz,

Incidentally, once bred in, mutations don't have the capability of 'reverting' back except through random mutation (incredibly unlikely in the timeframes we're dealing with). If one splices spider DNA into a silkworm and achieves homozygosity (which KBLB has done) then the only way you could get the silkworm gene back into the mix is if wild silkworms were allowed to breed with the Kraig worms. Proper husbandry eliminates this possibility.

With all due respect for your much greater knowledge of genetics, I think that there is one other way for genetic drift to happen (not to KBLB's lines but to some others).
Some early transgenic viral vectors (transposons) had the nasty habit of leaving bits of viral garbage in the genome which would cause genetic changes in later filial generations.
I believe this was what was commented on in the article by one of the principals behind Amsilk and was refferring to some of the Japanese work and some of RL's early ventures (before his connection with Fraser).
Correction of this problem was one of the main advancements of Malcolm Fraser's PiggyBac transposon which used a baculovirus that completely inactivated after one generation.
Please correct me if I am wrong or add more/better explanation.

Mike L.