Innovation Pharmaceuticals Inc (IPIX)

[To infinity and beyond!]

So nice of you to summarize a bit. When I read through such an important and chock full of info article I get lost in the trees ...

Some takeways: p53 has 393 amino acids and most have mutations expressed in cancers. A few of the mutations for p53 occur frequently in lots of cancers(the most common one is the 4th most common mutation seen with all cancers considered).

p53 mutations are overall very commonly expressed in various tumors, with a lovely table showing this distribution- almost all ovarian cancers, for example. But of course this includes all of the p53 mutants, and there are many!

As KMBJN just stated, just deleting p53 does not produce in mice the types of tumors found in humans BUT specific mutants do produce similar tumors.

Such an article helps me understand how complicated it all is. And I thought I knew how complicated it was yesterday. This review article helps muddy the waters, and bring them into focus at the same time. Certain drugs targeting p53 are likely to help with very specific tumor types, and there are many different ways to target mutant p53 action.

Learning how and if Kevetrin works in people will be fascinating.

What a find by you slcimmuno- most details I have come across.