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Monday, 05/11/2015 10:15:51 AM

Monday, May 11, 2015 10:15:51 AM

Post# of 92948
LOL quote, "RPE Therapy Works! All Patients Improved or Stabilized

These FACTs, are times 10, more important,
than all of the EXAGGERATED problems. "

NO, RPE "therapy" is being TESTED to "try" and prove it works and is safe. And the problems of OCAT are not "exaggerated", just read their own SEC FILINGS. Those aren't "FACTS"????

WHERE'S THE MONEY? They're on life support funding using a credit-card life line from Lincoln and are once again tapped out to close to their last dollar with about $12 million left, while they burn at least $2 million a month on the low side (and that's WITHOUT running a single large trial, let alone paying for it or funding it)- they just booked a massive $7 million plus loss for their latest qtr.

From the highly respected science journal NATURE:

www.nature.com/news/stem-cells-pass-safety-test-in-vision-loss-trial-1.17451

Lanza doesn't say "IT WORKS"??? He says CAUTION and MORE TESTING NEEDED to "prove" anything? He didn't dispute or retract or question the NATURE article? Why? He DOES NOT EVER SAY "it works" - he says MORE TESTING NEEDED, lots more testing and lots more MONEY.

The VERBATIM article, again, from the highly respected science journal, "NATURE"-

"A company that has spent more than 20 years trying to develop treatments based on embryonic stem cells is taking encouragement from small, preliminary tests of the cells in people with progressive vision loss. If the technique continues to impress in larger trials designed to assess its effectiveness, it could become the first therapy derived from embryonic stem cells to reach the market.

A study of four patients, published in Stem Cell Reports on 30 April1, shows that injection of retinal cells derived from stem cells is safe for people with macular degeneration. The report follows similar results from a trial in 18 patients that was published last October2.

Both studies were meant to assess safety only, and neither included a control group. In the latest study, conducted by researchers in Korea and the United States, three participants were able to read 9–19 more letters further on an eye chart a year after treatment — but two of the three also gained some ground in their untreated eyes."

MORE...

"“This bodes well,” says Robert Lanza, chief scientific officer at Ocata Therapeutics in Marlborough, Massachusetts, and an author of the study. “But I think we need to interpret this improvement cautiously until more controlled studies are done.”

The sample size is too small to warrant much excitement, cautions ophthalmologist Tien Yin Wong of the Singapore National Eye Centre. “At this stage it’s hard to say if the visual improvement will be sustained,” he says. “But it’s very promising.”

Lanza speaking to a local MA newspaper-

http://www.telegram.com/article/20141014/NEWS/310149525&Template=printart

"We treated the last UK patients last month, and they also have not seen any safety issues related to the transplanted tissues themselves, either," Dr. Lanza said.

Advanced Cell now hopes to launch a 100-patient, phase 2 study in Stargardt's patients by the end of the year, according to Dr. Lanza.

A second, smaller phase 2 study in patients with age-related macular degeneration would follow, he said. Any treatment might not be ready for FDA approval until 2020, Dr. Lanza said."


THOSE are the "FACTS" as Lanza has stated um "on the record"- not the other myths that this is a DONE DEAL and SLAM DUNK and already "proven" to work, blah, blah, blah.

That was dated Oct 14, 2014 and the END OF YEAR phase II DID NOT HAPPEN.

Where's the BIG MONEY? Why don't they ever attract any large capital investments- especially any "high quality" money (non dilutive) or at least not cash-for-dilution-shares deals with discounts and all the rest attached to them? Why? Why is that? Why? They live on low grade dilution money and have NO WHERE NEAR the funds to get a large Phase II even started- let alone funded to completion? Why? Why is that?

It took like FIVE YEARS to get a micro sized phase I done. They've yet to even start the large and magnitudes more difficult and magnitudes more expensive Phase II trials (with control arms and placebo blinding)- why? If the phase I took about FIVE YEARS, then how long will these phase II trials take- the one(s) that were supposedly going to be fully funded and rocking and rolling by END OF 2014 and it's now almost half way through 2015 and the trial(s) are in the parking space, going nowhere and the latest Lincoln cash is dwindling down at an alarming rate. Why? Why is that?

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