Generex Biotechnology Corp. (fka GNBTQ)

[WeeZuhl]

GNBT starting to get attention.

Welcome mick, stop by sometime! GLTA.

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One of our two main tech plays here is a drug-delivery system for the buccal delivery of various drugs (Rapid Mist). Many drugs are potential candidates for buccal delivery, which has multiple advantages, including rapid, painless systemic drug absorption, avoiding first-pass metabolism in the liver, and avoiding drug delivery to the lungs. Generex holds extensive international patents on this type of buccal delivery system. Drugs in active development include insulin and cannabis.

The other technology is a plug-and-play hybrid-peptide vaccine delivery system being developed by our wholly-owned subsidiary, Antigen Express. Any peptide vaccine can be plugged in and tagged with a 4 amino acid moiety (Ii-Key). The hybrid peptide is an MHC II epitope which has been proven to stimulate more robust CD4+ and CD8+ response than the peptide alone. The current vaccine under development, called AE-37, has completed Phase 2 and final results will be presented at ASCO this month. Preliminary results showed 49% reduction in risk of recuurent breast cancer but a much greater risk reduction (68%) in women with low HER2 expression, who are not eligible for current standard of care with Herceptin. GNBT longs are hopeful for an announcement soon on an AE-37 Phase 3 study, either alone or in combination with other petide vaccines. The same molecule is being tested in prostate cancer, but any peptide could be plugged in, and previous suggestions include influenza and ebola vaccines.

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