NanoViricides Inc. (NNVC)

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What Are the Different Types of Flu?
There are three types of flu viruses: A, B, and C. Type A and B cause the annual influenza epidemics that have up to 20% of the population sniffling, aching, coughing, and running high fevers. Type C also causes flu; however, type C flu symptoms are much less severe.

The flu is linked to between 3,000 and 49,000 deaths and 200,000 hospitalizations each year in the United States. The seasonal flu vaccine was created to try to avert these epidemics.

What Is Type A Flu Virus?
Type A flu or influenza A viruses are capable of infecting animals, although it is more common for people to suffer the ailments associated with this type of flu. Wild birds commonly act as the hosts for this flu virus.

Type A flu virus is constantly changing and is generally responsible for the large flu epidemics. The influenza A2 virus (and other variants of influenza) is spread by people who are already infected. The most common flu hot spots are those surfaces that an infected person has touched and rooms where he has been recently, especially areas where he has been sneezing.

What Is Type B Flu Virus?
Unlike type A flu viruses, type B flu is found only in humans. Type B flu may cause a less severe reaction than type A flu virus, but occasionally, type B flu can still be extremely harmful. Influenza type B viruses are not classified by subtype and do not cause pandemics.
Read more: http://www.webmd.com/cold-and-flu/flu-guide/advanced-reading-types-of-flu-viruses

With bird flu threat expected to linger...
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WHY PRODUCERS WANT A VACCINE

USDA officials have said the H5N2 virus could be a problem for the poultry industry for several years. The virus had already killed or led authorities to order the culling of nearly 2.3 million turkeys before it was confirmed Monday at an Iowa egg-laying operation with 3.8 million hens. And on Tuesday and Wednesday, five more turkey farms with more than 500,000 birds were added to the list.
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WHY THE USDA MIGHT DECIDE AGAINST A VACCINE

Introducing a vaccine raises a lot of questions, Myers said, including which poultry would get it, in what kind of settings, whether it would be effective in stopping the disease and potential negative effects on poultry exports.

James Sumner, president of the Georgia-based USA Poultry and Egg Export Council, said some countries might regard vaccine use as a reason to bar imports from the U.S. The vaccine could mask any viruses that poultry are carrying, because tests for the disease look for antibodies — the same antibodies that vaccines trigger a body to produce, he said.

Dr. Kyoungjin Yoon, an avian influenza expert at Iowa State University, said human experience shows flu vaccines don't always match well with viruses in circulation. Vaccine-induced immunity could also slow the detection of outbreaks, Yoon said. One of the main symptoms is that flocks start dying off quickly.
Read more: http://www.usnews.com/news/business/articles/2015/04/22/with-bird-flu-spreading-usda-starts-on-potential-vaccine

Treatment with NanoViricides FluCide™ Drug Candidates Resulted in a 1000-fold Reduction of Viral Load in the Lungs of Animals
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The amount of infectious virus in the lungs of the infected animals treated with three of the optimized FluCide™ nanoviricide drug candidates was reduced by greater than 1000-fold as compared to the infected untreated control animals (p-values < 0.001), four days after virus infection. In contrast, animals treated with Oseltamivir (Tamiflu®, Roche) showed less than a 2-fold reduction in lung viral load at the same time point. This indicated a 500-fold greater reduction in viral load by FluCide drug candidates over Oseltamivir.

Of great clinical significance is the fact that 2 of the optimized FluCide™ drug candidates maintained this greatly reduced lung viral load at 7, 13 and 19 days after virus infection in this 21 day study. Thus, treatment with FluCide drug candidates appeared to protect against the complete cycle of infection, virus expansion and spread of infection in the lungs that follows the initial virus infection. This was not the case for the oseltamivir-treated animals. Animals treated with Oseltamivir (Tamiflu®, Roche) showed less than a 2-fold reduction in lung viral load at 4 days and the viral load was increased at 7 days to the same level as that found in the infected, untreated control animals shortly before their death.
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http://www.fiercebiotech.com/press-releases/treatment-nanoviricides-flucide-drug-candidates-resulted-1000-fold-reductio

"We are agnostic to the host...we don't care if you are a man, a mouse, a whale or a salamander, as long as you have a virus in your system, we destroy it."~ Dr. Eugene Seymour, CEO NanoViricides, Inc.

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