Ariad Pharmaceuticals Inc fka ARIA

[Sikmarson]

Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

nature.com

..All patient samples showed a varied degree of sensitivity to BCR-ABL1 inhibitors, with ponatinib being the only BCR-ABL1 inhibitor that was effective in all patient samples (Figure 2). The cells of patient 1 that had an E255K mutation were only sensitive to dasatinib and ponatinib and showed minimal or no effect to other BCR-ABL1 inhibitors (for example, imatinib and nilotinib). Patient 2 had a T315I mutation and hence the patient cells were resistant to all primary BCR-ABL1 inhibitors except ponatinib and axitinib. Cells derived from patient 3 (with no mutation affecting BCR-ABL) were highly sensitive to all BCR-ABL1 inhibitors and the drug response profile resembled that of the TKI-sensitive cell lines (EM-2 and K-562)..