Generex Biotechnology Corp. (fka GNBTQ)

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Alternate Routes of Administration of Antidepressant and Antipsychotic Medications


Ann Pharmacother April 23, 2015

http://www.empr.com/alternate-administration-routes-for-psychotropic-drugs-reviewed/article/411332/

Buccal: Because buccal tissue is less readily permeable and results in slower absorption, medications with a long half-life and wide therapeutic range are targets for this administration. A case report of amitriptyline tablets crushed and dissolved in a patient's mouth to promote buccal absorption was found in the review, along with a study on selegiline ODT administration for buccal absorption in which MAO-A inhibition was similar to a transdermal delivery system.

The authors conclude that development of alternative formulations could assist clinicians in treating patients with psychiatric disorders who cannot tolerate oral or injectable forms of medication and prevent discontinuation of drug therapy due to administration barriers.

There is potential for buccal delivery (i.e. Generex Rapid Mist) of antidepressants, anxiolytics, and anti-psychotics.