Innovation Pharmaceuticals Inc (IPIX)

[To infinity and beyond!]

I think that any extra bit of antimicrobial activity is helpful, and I have looked at the gm- coverage for Brilacidin a month or 2 back. It does well against EColi, but not so well against others, as I recall. And yes, that is why it is not mentioned, in part. BUT, also: they do not have to talk about gm- at all with B for the trials because for most patients with cellulitis and abscesses because those problems are caused by gm+ bugs. Just look at the isolates of bacteria for the phase 2 data.

Who gets gm- cellulitis/abscess? Almost no one- IV drug users sometimes, and diabetics sometimes.

The company mentions diabetic foot infections, and I wonder if they intend Brilacidin for this as well, but typically anaerobic coverage is also required, plus some gm- too.

What I find fascinating about the whole thing is the other indications for using Brilacidin, if they pan out. Immunomodulator activity. The mucositis data looks pretty good, right? And wouldn't we like to know what they have to show the FDA about ulcerative colitis? That is a BIG market, esp if they can expand it to all of the colon and not just the last bit of it. Really interesting stuff.