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Wednesday, April 01, 2015 1:29:56 AM
Thanks to whoever piggybacked this to yahoo, and boiler for the answer!
No vasculization-OK
Is it still only 8 layers thick, and does this mean 8 cells, liver cells, thick?
thanks
btw I kinda started to hate Minger for his dismissile? of ONVO,
but maybe he was just rushed, heh.
Unless, of course, GE is the one behind the 16 million short position,
a hundred million dollars worth, of shorting behind the crushing of
ONVO.
I kinda hate whoever is behind this.
boilerupvic
Well technically he isn't wrong. I'll try to explain this in laymen terms. Most bioprinting uses a scaffolding or hydrogel approach. Organovo does drop cells into a dish, but they do it in specific patterns with incredible accuracy in X,Y and Z. When dropping different cells in conjunction with one another they naturally form specific shapes and sizes. This method (to my knowledge) most closely resembles human anatomy and tissue density. The trouble comes with building out a vascular network to increase the thickness of the tissue. This is a problem that literally everyone in bioprinting has.
There are multiple studies utilizing different angles to try to tackle this problem each showing promises in different areas. Some use hydro-gels, luckily for Onvo, they can also use hydro-gels when needed (it just isn't necessary for any of their commercial products at the moment or in the pipeline).
The important thing here is that currently no one has an answer for this problem. Organovo has products already in the pipeline that will generate revenue as they continue R&D. In addition to this, they have great scientific advisors, partnerships and collaboration with universities.
Dr. Stephen Minger comes off extremely dismissive and downplays a promising technology. It seemed like he was trying to hurry his talk along, but in the process failed to clarify why everyone is trying to work together to solve this problem. We don't know if/when will be able to print working vasculature, but we're making great progress and that's enough for me.
Recent ONVO News
- Form 10-K/A - Annual report [Section 13 and 15(d), not S-K Item 405]: [Amend] • Edgar (US Regulatory) • 07/26/2024 08:05:03 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 07/24/2024 08:05:07 PM
- Organovo Highlights FXR314 Near Term Value Catalysts at Jones Trading Conference Strong Preclinical and Human Rationale for FXR314 in P2 2 Ulcerative Colitis • GlobeNewswire Inc. • 07/16/2024 12:05:44 PM
- Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405] • Edgar (US Regulatory) • 05/31/2024 08:05:33 PM
- Organovo Data Presented at Digestive Disease Week (DDW2024) Demonstrating Potential for FXR314 as Combination Therapy with Tofacitinib for Inflammatory Bowel Disease • GlobeNewswire Inc. • 05/21/2024 12:05:35 PM
- Form 424B4 - Prospectus [Rule 424(b)(4)] • Edgar (US Regulatory) • 05/14/2024 04:45:20 PM
- Organovo to Present Data on FXR314 at Digestive Diseases Week (DDW2024) • GlobeNewswire Inc. • 05/14/2024 03:00:21 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/13/2024 09:00:35 PM
- Form 424B4 - Prospectus [Rule 424(b)(4)] • Edgar (US Regulatory) • 05/10/2024 09:15:22 PM
- Organovo Holdings, Inc. Announces Pricing of $5.25 Million Public Offering • GlobeNewswire Inc. • 05/09/2024 12:00:12 AM
- Organovo Announces Positive Phase 2 Results for FXR314 in Metabolic Dysfunction-Associated Steatohepatitis (MASH) Showing Both Reduction in Liver Fat Content and Strong Safety and Tolerability Compared to Placebo • GlobeNewswire Inc. • 04/15/2024 12:05:00 PM
- Form EFFECT - Notice of Effectiveness • Edgar (US Regulatory) • 02/09/2024 05:15:07 AM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 02/08/2024 09:56:43 PM
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- Form 8-K - Current report • Edgar (US Regulatory) • 02/07/2024 01:05:17 PM
- Form S-3 - Registration statement under Securities Act of 1933 • Edgar (US Regulatory) • 01/26/2024 10:09:03 PM
- Organovo Presents FXR314 3D Human Tissue Model Findings That Show Improved Epithelial Barrier Function and Fibrosis Reduction at Crohn’s and Colitis Congress • GlobeNewswire Inc. • 01/25/2024 01:05:00 PM
- Organovo To Present FXR314 IBD 3D Model Findings at Upcoming Crohn’s and Colitis Congress • GlobeNewswire Inc. • 01/09/2024 01:05:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 12/28/2023 09:05:09 PM
- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 12/22/2023 11:05:02 AM
- Organovo Provides Timing for Release of FXR314 Phase 2 NASH Results • GlobeNewswire Inc. • 12/06/2023 01:05:00 PM
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