Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

How We Age in The Scientist Magazine, From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.,
By The Scientist Staff | March 1, 2015

Excerpts:
"“We age so completely and in so many different ways,” says stem cell biologist Derrick Rossi of Harvard University. “We are programmed to die.”"

"Other scientists are focusing on the transcription factor NF-?B, a central activator of inflammation, as a driver of aging. Overactivation of NF-?B may cause senescent cells to release cytokines that stimulate inflammation and lead to further degeneration, even in far-flung parts of the body. “It seems that with almost anything that activates NF-?B, if you reduce it, it improves aging,” says Robbins. He and his colleagues have demonstrated that inhibiting NF-?B can stave off cell senescence in mice that age prematurely due to DNA repair defects (J Clin Invest, 122:2601-12, 2012). “[We want] to see if we can understand the contribution of what goes on within a cell versus the contribution of what that cell secretes that affects cells at a distance,” he says. —Molly Sharlach"

Article at:
http://www.the-scientist.com/?articles.view/articleNo/42280/title/How-We-Age/