BioCurex, Inc.(fka BOCX)

[scouty]

online A–Z of cancer genes mutations
20 March 2004

Building on the cancer gene census, the Cancer Genome Project team has also embarked on the ambitious task of cataloguing all the mutations in the genes that have been associated with cancer. The first fruits of their labours, the online database COSMIC (catalogue of somatic mutations in cancer), was launched in February 2004.

A huge body of information has accumulated about the different mutations affecting these genes. Currently, researchers have to go to many different sources to gather this data. A single, coherent and comprehensive resource – an A–Z of cancer genes and their mutations – will be an invaluable resource in cancer genetics and cancer biology.

The first phase of COSMIC includes data on four genes – BRAF, HRAS, KRAS2 and NRAS – and the scale of the task is already clear. Take the KRAS2 gene, for example: over the years, more than 35 000 tumours have been tested, more than 8000 mutations have been found, and they were reported in more than 700 papers.

COSMIC already holds information on 57 444 tumours and reports a total of 10 647 mutations. Ultimately, however, it will include information on all genes that are somatically mutated in human cancer.

For further information visit the COSMIC database and website.

http://www.wellcome.ac.uk/doc_WTX031289.html>

<http://snipurl.com/qhbk>

Quite comprehensive website gathering virtually every conceivable research issue on cancer-I'm looking for references to the recaf cell/tissue/mutation..perhaps the research guru's can help-scouty