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$PMCB on alert for Wednesday, huge news from this morning too.

PharmaCyte Biotech's Scientific Advisory Board Chairman Publishes Review Article on the Pathology of Pancreatic Cancer

http://finance.yahoo.com/news/pharmacyte-biotechs-scientific-advisory-board-143000677.html

SILVER SPRING, Md., Feb. 24, 2015 (GLOBE NEWSWIRE) -- PharmaCyte Biotech, Inc. (PMCB), a clinical stage biotechnology company focused on developing targeted treatments for cancer and diabetes using its signature live-cell encapsulation technology, Cell-in-a-Box(R), announced today that Dr. Matthius Lohr, Chairman of its Scientific Advisory Board, together with his colleagues Dr. Verbeke, Dr. Severin Karlsson and Dr. Del Charro from the Karolinska Institute in Stockholm, Sweden, have published a medical and scientific review article that is directed to improving the treatment of pancreatic cancer. The article titled "Pathology reporting of pancreatic cancer following neoadjuvant chemotherapy: Challenges and uncertainties" appeared in the renowned cancer journal Cancer Treatment Reviews. The review can be viewed by clicking here, scrolling down to the article's title and then clicking on "PDF."

The review article highlights the lack of recommendations for the macroscopic examination, tissue sampling and microscopic assessment of pancreatic cancer as well as the grading of tumor regression and assessment of residual tumor tissue, in contrast to those seen with other cancers. All of these factors are important parameters in assessing treatment outcome in clinical trials of patients with pancreatic cancer undergoing neoadjuvant therapy (used to shrink a tumor prior to additional treatment such as surgery) and the divergence of these matters among pancreatic cancer clinical trials makes interpretation of trial results and comparisons among trials quite difficult. Accordingly, the authors of the review article have made interim suggestions for dealing with these criteria and call for an international consensus on dealing with these critical parameters.

Kenneth L. Waggoner, CEO of PharmaCyte Biotech, stated, "Prof. Lohr and his colleagues have highlighted a major deficit in the diagnosis, treatment and the evaluation of treatment success in pancreatic cancer in this important publication. Not only is this relevant for the future treatment of pancreatic cancer, but it is also a key for measuring success in clinical trials in comparison to other treatments. All of the factors discussed in this review article should be considered in conducting trials in patients with pancreatic cancer which, of course, includes our upcoming Phase 2b clinical trial."

In commenting on the review article, Dr. Lohr emphasized, "Despite the fact that pathology provides key outcome parameters in terms of tumor regression and completeness of surgical resection following neoadjuvant treatment, worldwide there are inconsistencies in various aspects of pathology examination such as specimen dissection, tissue sampling, evaluation of tumor regression and margin status assessment which can confound diagnosis as well as evaluation of treatment success in pancreatic cancer. We are calling for international consensus on these critical parameters since we believe that this is of utmost importance as we move towards newer treatments for this devastating disease."