Tuesday, February 03, 2015 9:31:23 AM
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Calimmune’s researchers have used stem cell technology to create T cells lacking the CCR5 gene receptor, thus making them resistant to HIV. These manually mutated cells are then reintroduced into the patient’s body via an outpatient transplant procedure that is more effective and safer than a standard bone marrow transplant. The latter, says Dr. Scott Hammer, a scientist at the HIV/AIDS research program at New York’s Columbia University Medical Center, is too “toxic” of a procedure to be considered as a general treatment for HIV.
The transplant “gives them a population of cells that are not infected,” says Baltimore. These uninfected cells could then either control the virus numbers in HIV-positive individuals or prevent infection in those without it. In other words, the transplant has the potential to be both cure and vaccine. Calimmune has announced it is about to move on to the second half of its Phase 1 human trial, and will soon implant four new patients with its genetically modified stem cells.
http://www.newsweek.com/2015/02/13/mystery-elite-controller-and-how-we-will-cure-hiv-303936.html
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