Avid Bioservices Inc (CDMO)

[sulaco]

MD, if you do a little algebra, you can see that

The 7 patients still alive must average 14.4 months TTP for the total 38 patients to average 8.2 months TTP. Remember, the study is powered only to detect this far out, not more.

For example:

31 patients (6.8 TTP obtained ) + 7 patients (x) = 38 patients (8.2 TTP average)

7x = 311.6-210.8

7x = 100.8

x = 14.4 months TTP (time to progression)

Can these 7 patients do it? Well, they're still on their way. They would all have to live until September 20, 2015 for the average to occur. Present median trial time is 6.1 months, which means to make 14.4 months TTP, they have to live another 8.3 months. 8.3 months from now is about September 20, 2015, give or take. We'll see.

Regards,

Joe