JO,
There is no dispute that higher the sensitivity lower the specificity but you view it as negative and I'm not and I will explain in detail. This is after reading JN article in SA.
For now lets consider airport security as an example.
When you go through airport security process there are two scanners one for scanning low risk items like shoes, belts, wallets etc. (low specificity) that donot pose threat to the airline. There is another scanner which scans body, it is possible something hidden in your clothes that can pose threat to airline like hazardous material(high sensitivity). The body scanner may not be perfect to scan smaller items which is done by specific scanner.
For instance, in an airport security setting in which one is testing for potential threats to safety, scanners may be set to trigger on low-risk items like belt buckles and keys (low specificity), in order to reduce the risk of missing objects that do pose a threat to the aircraft and those aboard (high sensitivity).
In short, there are two different tests that do specific job to make sure your trip is safe and secure.
Now you can relate this example to Lympro Version 1 and 2. Version 1 finds true negative patients whereas version 2 finds true positives.
Version 1 and 2 are prepared with specific stimulation levels and incubation times. These parameters can be adjusted to find higher true positives or negatives.
Considering airport security example I'm more inclined to think that AMBS should use both versions to get higher sensitivity and specificity. Once the blood sample is collected it can be processed in parallel with version 1 and 2 since version 1 gives you high spec,low sens and Version 2 gives high sens, low spec.
