Avid Bioservices Inc (CDMO)

[md1225]

CP I was referring to this study.

EBS is here daily as many longs I respect are they just don't post. I would appreciate his input.

If BAVI shows even 50% improvement of the improvement it did in Phase II, it will still be ahead !! Below is from ASCO 2013.
Boehringer Ingelheim's nintedanib has become the first drug in more than 10 years to improve survival in lung cancer patients whose disease had progressed despite chemotherapy.

The results of the LUME-Lung 1 trial, presented at the American Society of Clinical Oncology (ASCO) meeting in Chicago, showed that the drug extended survival by 2.3 months compared to placebo when added to docetaxel therapy in non-small cell lung cancer (NSCLC) patients with adenocarcinomas.

The orally-active drug was unable to improve overall survival for the entire NSCLC patient population enrolled into the study, which also included patients with squamous-type tumours, although there was a trend towards a benefit.

The primary clinical measure in the study was progression-free survival (PFS), and on this endpoint the combination of nintedanib and docetaxel had a modest effect, delaying progression by three weeks compared to docetaxel and placebo, which was a statistically significant difference.

The effect on PFS was seen in both squamous and adeno NSCLC patients, but the effect was much stronger in the latter group with an improvement compared to placebo of 1.2 months.

Nintedanib is an investigational triple angiokinase inhibitor that targets three of the receptor tyrosine kinases (FGFR, PDGFR, and VEGFR) involved in the formation of new blood vessels (angiogenesis) in tumour tissue.

"This is the first time an anti-angiogenic treatment has shown a real benefit for NSCLC patients after initial chemotherapy has failed," commented Martin Reck of the Lung Clinic Grosshansdorf in Germany, who was the principal investigator in the trial and presented the data at ASCO.