Innovation Pharmaceuticals Inc (IPIX)

[georgejjl]

What level of P21/P53 activation is needed/desired?
Why /how was 10% selected as the threshold?

"P21 increased in 6 out of 14 patients"

Actual wording of slide:

P21 increased > 10% in 6 out of 14 patients at relatively low doses of Kevetrin


Last year the wording was:

Kevetrin activated p21 in 4 of 5 patients ...

So, my view is that K may have activated p21 in more than the 6 of 14 as shown on the slide, but some were below the 10% threshold. Perhaps it was 11 of 12 that showed "activation".

This particular slide (2014, slide #4) also has the DF & BI logo at the bottom. I believe that CTIX cleared this slide and all K related content of this presentation with DF & BI and they approved this.

What level of P21/P53 activation is needed/desired?
Why /how was 10% selected as the threshold?

Good luck and GOD bless,

George