Based on the Tasigna study, a ten percent dose of Ponatinib of 10mg may be sufficient especially as Ponatinib is stronger than Tasigna. It is feasible that this low dosage may mitigate the SAEs. For Berger not to pursue this indication because of possible SAEs would be just another reason we need a change of leadership. I hope Denner will push a partnership for this incredibly lucrative indication.
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