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Alias Born 10/25/2014

Re: frontiers post# 182994

Saturday, 10/25/2014 7:47:08 PM

Saturday, October 25, 2014 7:47:08 PM

Post# of 252581
very nice analysis on ACH3422. I totally agree with you for all the points.

The 20140309189 patent shows Alios 6037, which has also 2 deuteriums at 5' position. Did you check further their patents? any conflict?

Alios Bio. has recently published a paper. They have checked the potency of the "non-deuterium verison" of ACH3422-TP, and the potency is similar to Sovaldi-TP. I feel ACH3422 should have similar potency as Sovaldi, but more toxic. But anyway, for P1, this difference in toxic is not so important.

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