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Wednesday, October 22, 2014 9:30:36 PM
How did you come to the conclusion that it is the micelle production is the limiting factor?
Logic, a hard-earned working knowlege of Chemistry, and an educated guess or two on my part. I could be wrong, but that would seem to be the important part (and probably the sticking point) when scaling up production.
The ligands, once synthesized, are bonded to a standardized set of PEG-based micelles. The ligand molecules (if I understood the presentation a month or so ago) are made by an outside contractor, and are made to order and shipped to NNVC. I would guess that doesn't present a scale-up problem for NNVC in particular if they are getting that part made by an outside contractor.
The micelles are essentially a modular component and should be relatively common to pretty much any formulation of 'Cide. As that is a component common to all 'Cides, that's a part they are going to need to be able to make in quantity.
Also - when Dr. Seymour was giving that talk a month or so ago he was describing how NNVC was planning on running the new Shelton plant on a 'Just In Time' production model where "working stocks" (I would have to go back to the transcript for the exact words Dr. Seymour used) of the micelle would be essentially kept on the shelf and target-specific ligands added as needed for different 'Cides.
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