Eleven VRTX insiders sold cumulative $72M of stock during the past two months under 10b5-1 plans… • CEO $22.5M on 9/30/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114060604/xslF345X03/doc4.xml • Chairman $4.5M on 8/6/14 through 10/1/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114051126/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114052732/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114053930/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114054884/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114056154/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114057779/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114058791/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114059943/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114061626/xslF345X03/doc4.xml • COO $6.9M on 9/19/14 and 10/1/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114059299/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114061653/xslF345X03/doc4.xml • CFO $9.9M on 9/30/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114060584/xslF345X03/doc4.xml • General Counsel $4.1M on 9/30/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114060597/xslF345X03/doc4.xml • SVP $9.7M on 9/30/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114060588/xslF345X03/doc4.xml • SVP $6.4M on 9/30/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114060592/xslF345X03/doc4.xml • SVP $2.5M on 9/19/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114059303/xslF345X03/doc4.xml • SVP $1.7M on 9/30/14 and 10/1/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114060582/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114061636/xslF345X03/doc4.xml • CMO $0.4M on 10/7/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114062640/xslF345X03/doc4.xml • Director $2.6M on 9/5/14 through 10/6/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114057168/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114059297/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114059946/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114060234/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114061642/xslF345X03/doc4.xml http://www.sec.gov/Archives/edgar/data/875320/000120919114062466/xslF345X03/doc4.xml • Director $0.5M on 10/1/14: http://www.sec.gov/Archives/edgar/data/875320/000120919114061668/xslF345X03/doc4.xml