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Re: MONEYMADE post# 27

Thursday, 10/02/2014 7:44:41 PM

Thursday, October 02, 2014 7:44:41 PM

Post# of 1954
ABIO is not in your list- Company got the exclusive rights for rNAPc2 from Dendreon few years ago. http://www.wikinvest.com/stock/Nuvelo_%28NUVO%29/Dendreon
They wait for government funding. 33% survival rate(monkeys).

http://jid.oxfordjournals.org/content/204/suppl_3/S1043.long

http://www.ncbi.nlm.nih.gov/pubmed/14683653

Both treatment regimens prolonged survival time, with a 33% survival rate in each treatment group. Survivors are still alive and healthy after 9 months. All but one of the 17 controls died. The mean survival for the six rNAPc2-treated macaques that died was 11.7 days compared with 8.3 days for untreated controls (p=0.0184). rNAPc2 attenuated the coagulation response as evidenced by modulation of various important coagulation factors, including plasma D dimers, which were reduced in nearly all treated animals; less prominent fibrin deposits and intravascular thromboemboli were observed in tissues of some animals that succumbed to Ebola virus. Furthermore, rNAPc2 attenuated the proinflammatory response with lower plasma concentrations of interleukin 6 and monocyte chemoattractant protein-1 (MCP-1) noted in the treated than in the untreated macaques.


We also hold exclusive rights to rNAPc2, a single-chain, small recombinant protein, originally isolated from the saliva of the canine hookworm.
rNAPc2 is a potent, long acting, and selective inhibitor of tissue factor, the protein responsible for initiating the extrinsic coagulation pathway, the primary coagulation mechanism in humans. rNAPc2 was originally developed as
a cardiovascular therapy for thrombosis and other indications. As a result, it has been safely tested in over 700 human patients in nine Phase 1 and Phase 2 clinical trials.
Previously, pilot studies of rNAPc2 conducted in non-human primates demonstrated potential efficacy against two of the most deadly strains of hemorrhagic fever virus, Ebola and Marburg.
We are currently seeking government funding to further develop rNAPc2, as a potential treatment for viral hemorrhagic fevers. Considering the substantial cost associated with the development of rNAPc2 and our limited financial resources, further development of rNAPc2 will be dependent upon receipt of government funding, which may not be available.



Read more: http://www.nasdaq.com/markets/spos/company/arca-biopharma-inc-9177-66534#ixzz3Ew9X9w00

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