Amarantus Bioscience Holdings Inc (AMBS)

[Rosym]

The binding of extracellular signal molecules to either cell-surface receptors or intracellular receptors. Most signal molecules are hydrophilic and are therefore unable to cross the plasma membrane directly; instead, they bind to cell-surface receptors.


Fumi - We are still looking for an answer. It seems like that MANF binds to another molecule in our cells and activate enzymes important for cell survival. So our strategy is to manipulate this process using a small molecule (i.e., a drug). This is aligned with our strategy #2.